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In NSCLC, Alimta is approved for various settings, including initial treatment in combination with cisplatin for locally advanced or metastatic non-squamous NSCLC, as maintenance therapy after initial chemotherapy, and as a single agent for patients with locally advanced or metastatic non-squamous NSCLC after prior chemotherapy

These authors showed that a ligand-free ligand binding domain (LBD) of PPAR is significantly more flexible than the rest of the LBD, indicating that this binding pocket is intrinsically disordered in order to accommodate different ligands (Hamuro et al., 2006)

Model 1 was adjusted for age (years, continuous variables), sex (male, female), and race/ethnicity (non-Hispanic white, black, Hispanic Mexican, or other)

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A 2025 pilot study tested IV BPC-157 up to 20 mg in 2 healthy adults for safety only, finding it well tolerated but conducting no efficacy testing